Multilevel Approach of a 1-Year Program of Dietary and Exercise Interventions on Bone Mineral Content and Density in Metabolic Syndrome – the RESOLVE Randomized Controlled Trial
Identifieur interne : 002B16 ( Main/Exploration ); précédent : 002B15; suivant : 002B17Multilevel Approach of a 1-Year Program of Dietary and Exercise Interventions on Bone Mineral Content and Density in Metabolic Syndrome – the RESOLVE Randomized Controlled Trial
Auteurs : Daniel Courteix [France, Australie] ; João Valente-Dos-Santos [Portugal] ; Béatrice Ferry [France] ; Gérard Lac [France] ; Bruno Lesourd [France] ; Robert Chapier [France] ; Geraldine Naughton [Australie] ; Geoffroy Marceau [France] ; Manuel João Coelho-E-Silva [Portugal] ; Agnès Vinet [France] ; Guillaume Walther [France] ; Philippe Obert [France] ; Frédéric Dutheil [France, Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- diétothérapie : Syndrome métabolique X.
- physiopathologie : Syndrome métabolique X.
- Adulte d'âge moyen, Densité osseuse, Exercice physique, Femelle, Humains, Mâle, Observance thérapeutique, Régime alimentaire, Études de suivi, Études longitudinales.
English descriptors
- KwdEn :
- MESH :
- diet therapy : Metabolic Syndrome X.
- physiopathology : Metabolic Syndrome X.
- statistics & numerical data : Patient Compliance.
- Bone Density, Diet, Exercise, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged.
Abstract
Weight loss is a public health concern in obesity-related diseases such as metabolic syndrome (MetS). However, restrictive diets might induce bone loss. The nature of exercise and whether exercise with weight loss programs can protect against potential bone mass deficits remains unclear. Moreover, compliance is essential in intervention programs. Thus, we aimed to investigate the effects that modality and exercise compliance have on bone mineral content (BMC) and density (BMD).
We investigated 90 individuals with MetS who were recruited for the 1-year RESOLVE trial. Community-dwelling seniors with MetS were randomly assigned into three different modalities of exercise (intensive resistance, intensive endurance, moderate mixed) combined with a restrictive diet. They were compared to 44 healthy controls who did not undergo the intervention.
This intensive lifestyle intervention (15–20 hours of training/week + restrictive diet) resulted in weight loss, body composition changes and health improvements. Baseline BMC and BMD for total body, lumbar spine and femoral neck did not differ between MetS groups and between MetS and controls. Despite changes over time, BMC or BMD did not differ between the three modalities of exercise and when compared with the controls. However, independent of exercise modality, compliant participants increased their BMC and BMD compared with their less compliant peers. Decreases in total body lean mass and negative energy balance significantly and independently contributed to decreases in lumbar spine BMC.
After the one year intervention, differences relating to exercise modalities were not evident. However, compliance with an intensive exercise program resulted in a significantly higher bone mass during energy restriction than non-compliance. Exercise is therefore beneficial to bone in the context of a weight loss program.
ClinicalTrials.gov
Url:
DOI: 10.1371/journal.pone.0136491
PubMed: 26376093
PubMed Central: 4574281
Affiliations:
- Australie, France, Portugal
- Auvergne (région administrative), Auvergne-Rhône-Alpes, Provence-Alpes-Côte d'Azur
- Avignon, Clermont-Ferrand
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Le document en format XML
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id="aff003"><addr-line>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Valente Dos Santos, Joao" sort="Valente Dos Santos, Joao" uniqKey="Valente Dos Santos J" first="João" last="Valente-Dos-Santos">João Valente-Dos-Santos</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>Lusófona University of Humanities and Technologies, Faculty of Physical Education and Sport, Lisbon, Portugal</addr-line></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>Lusófona University of Humanities and Technologies, Faculty of Physical Education and Sport, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>University of Coimbra, Faculty of Sport Sciences and Physical Education, Research Unit for Sport and Physical Activity (CIDAF), Coimbra, Portugal</addr-line></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>University of Coimbra, Faculty of Sport Sciences and Physical Education, Research Unit for Sport and Physical Activity (CIDAF), Coimbra</wicri:regionArea><wicri:noRegion>Coimbra</wicri:noRegion></affiliation></author><author><name sortKey="Ferry, Beatrice" sort="Ferry, Beatrice" uniqKey="Ferry B" first="Béatrice" last="Ferry">Béatrice Ferry</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Lac, Gerard" sort="Lac, Gerard" uniqKey="Lac G" first="Gérard" last="Lac">Gérard Lac</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Auvergne University, Faculty of Medicine, Geriatric, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Auvergne University, Faculty of Medicine, Geriatric, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Naughton, Geraldine" sort="Naughton, Geraldine" uniqKey="Naughton G" first="Geraldine" last="Naughton">Geraldine Naughton</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Australian Catholic University, Faculty of Health, School of Exercise Science, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, Faculty of Health, School of Exercise Science, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Marceau, Geoffroy" sort="Marceau, Geoffroy" uniqKey="Marceau G" first="Geoffroy" last="Marceau">Geoffroy Marceau</name><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>University Hospital of Clermont-Ferrand (CHU), Biochemistry, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Clermont-Ferrand (CHU), Biochemistry, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Joao Coelho E Silva, Manuel" sort="Joao Coelho E Silva, Manuel" uniqKey="Joao Coelho E Silva M" first="Manuel" last="João Coelho-E-Silva">Manuel João Coelho-E-Silva</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>University of Coimbra, Faculty of Sport Sciences and Physical Education, Research Unit for Sport and Physical Activity (CIDAF), Coimbra, Portugal</addr-line></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea>University of Coimbra, Faculty of Sport Sciences and Physical Education, Research Unit for Sport and Physical Activity (CIDAF), Coimbra</wicri:regionArea><wicri:noRegion>Coimbra</wicri:noRegion></affiliation></author><author><name sortKey="Vinet, Agnes" sort="Vinet, Agnes" uniqKey="Vinet A" first="Agnès" last="Vinet">Agnès Vinet</name><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Laboratory of Pharm-Ecology Cardiovascular (EA4278), University of Avignon, Avignon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Pharm-Ecology Cardiovascular (EA4278), University of Avignon, Avignon</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Laboratory of Pharm-Ecology Cardiovascular (EA4278), University of Avignon, Avignon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Pharm-Ecology Cardiovascular (EA4278), University of Avignon, Avignon</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Laboratory of Pharm-Ecology Cardiovascular (EA4278), University of Avignon, Avignon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Pharm-Ecology Cardiovascular (EA4278), University of Avignon, Avignon</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Avignon</settlement></placeName></affiliation></author><author><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Clermont Auvergne University, Blaise Pascal University, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological conditions (AME2P, EA3533), Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Australian Catholic University, Faculty of Health, School of Exercise Science, Melbourne, Victoria, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Australian Catholic University, Faculty of Health, School of Exercise Science, Melbourne, Victoria</wicri:regionArea><wicri:noRegion>Victoria</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff003"><addr-line>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Research Centre in Human Nutrition (CRNH) Auvergne, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>University Hospital of Clermont-Ferrand (CHU), Preventive and Occupational Medicine, Clermont-Ferrand, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University Hospital of Clermont-Ferrand (CHU), Preventive and Occupational Medicine, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bone Density</term><term>Diet</term><term>Exercise</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Metabolic Syndrome X (diet therapy)</term><term>Metabolic Syndrome X (physiopathology)</term><term>Middle Aged</term><term>Patient Compliance (statistics & numerical data)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Densité osseuse</term><term>Exercice physique</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Observance thérapeutique ()</term><term>Régime alimentaire</term><term>Syndrome métabolique X (diétothérapie)</term><term>Syndrome métabolique X (physiopathologie)</term><term>Études de suivi</term><term>Études longitudinales</term></keywords><keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="diétothérapie" xml:lang="fr"><term>Syndrome métabolique X</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Syndrome métabolique X</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Patient Compliance</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Bone Density</term><term>Diet</term><term>Exercise</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Densité osseuse</term><term>Exercice physique</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Observance thérapeutique</term><term>Régime alimentaire</term><term>Études de suivi</term><term>Études longitudinales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Weight loss is a public health concern in obesity-related diseases such as metabolic syndrome (MetS). However, restrictive diets might induce bone loss. The nature of exercise and whether exercise with weight loss programs can protect against potential bone mass deficits remains unclear. Moreover, compliance is essential in intervention programs. Thus, we aimed to investigate the effects that modality and exercise compliance have on bone mineral content (BMC) and density (BMD).</p></sec><sec id="sec002"><title>Methods</title><p>We investigated 90 individuals with MetS who were recruited for the 1-year RESOLVE trial. Community-dwelling seniors with MetS were randomly assigned into three different modalities of exercise (intensive resistance, intensive endurance, moderate mixed) combined with a restrictive diet. They were compared to 44 healthy controls who did not undergo the intervention.</p></sec><sec id="sec003"><title>Results</title><p>This intensive lifestyle intervention (15–20 hours of training/week + restrictive diet) resulted in weight loss, body composition changes and health improvements. Baseline BMC and BMD for total body, lumbar spine and femoral neck did not differ between MetS groups and between MetS and controls. Despite changes over time, BMC or BMD did not differ between the three modalities of exercise and when compared with the controls. However, independent of exercise modality, compliant participants increased their BMC and BMD compared with their less compliant peers. Decreases in total body lean mass and negative energy balance significantly and independently contributed to decreases in lumbar spine BMC.</p></sec><sec id="sec004"><title>Conclusion</title><p>After the one year intervention, differences relating to exercise modalities were not evident. However, compliance with an intensive exercise program resulted in a significantly higher bone mass during energy restriction than non-compliance. Exercise is therefore beneficial to bone in the context of a weight loss program.</p></sec><sec id="sec005"><title>Trial Registration</title><p>ClinicalTrials.gov <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT00917917">NCT00917917</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pedersen, Sd" uniqKey="Pedersen S">SD Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shapses, Sa" uniqKey="Shapses S">SA Shapses</name></author><author><name sortKey="Riedt, Cs" uniqKey="Riedt C">CS Riedt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hinton, Ps" uniqKey="Hinton P">PS Hinton</name></author><author><name sortKey="Lecheminant, Jd" uniqKey="Lecheminant J">JD LeCheminant</name></author><author><name sortKey="Smith, Bk" uniqKey="Smith B">BK Smith</name></author><author><name sortKey="Rector, Rs" uniqKey="Rector R">RS Rector</name></author><author><name sortKey="Donnelly, Je" uniqKey="Donnelly J">JE Donnelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sukumar, D" uniqKey="Sukumar D">D Sukumar</name></author><author><name sortKey="Ambia Sobhan, H" uniqKey="Ambia Sobhan H">H Ambia-Sobhan</name></author><author><name sortKey="Zurfluh, R" uniqKey="Zurfluh R">R Zurfluh</name></author><author><name sortKey="Schlussel, Y" uniqKey="Schlussel Y">Y Schlussel</name></author><author><name sortKey="Stahl, Tj" uniqKey="Stahl T">TJ Stahl</name></author><author><name sortKey="Gordon, Cl" uniqKey="Gordon C">CL Gordon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Redman, Lm" uniqKey="Redman L">LM Redman</name></author><author><name sortKey="Rood, J" uniqKey="Rood J">J Rood</name></author><author><name sortKey="Anton, Sd" uniqKey="Anton S">SD Anton</name></author><author><name sortKey="Champagne, C" uniqKey="Champagne C">C Champagne</name></author><author><name sortKey="Smith, Sr" uniqKey="Smith S">SR Smith</name></author><author><name sortKey="Ravussin, E" uniqKey="Ravussin E">E Ravussin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamilton, Kc" uniqKey="Hamilton K">KC Hamilton</name></author><author><name sortKey="Fisher, G" uniqKey="Fisher G">G Fisher</name></author><author><name sortKey="Roy, Jl" uniqKey="Roy J">JL Roy</name></author><author><name sortKey="Gower, Ba" uniqKey="Gower B">BA Gower</name></author><author><name sortKey="Hunter, Gr" uniqKey="Hunter G">GR Hunter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Villareal, Dt" uniqKey="Villareal D">DT Villareal</name></author><author><name sortKey="Chode, S" uniqKey="Chode S">S Chode</name></author><author><name sortKey="Parimi, N" uniqKey="Parimi N">N Parimi</name></author><author><name sortKey="Sinacore, Dr" uniqKey="Sinacore D">DR Sinacore</name></author><author><name sortKey="Hilton, T" uniqKey="Hilton T">T Hilton</name></author><author><name sortKey="Armamento Villareal, R" uniqKey="Armamento Villareal R">R Armamento-Villareal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Villareal, Dt" uniqKey="Villareal D">DT Villareal</name></author><author><name sortKey="Fontana, L" uniqKey="Fontana L">L Fontana</name></author><author><name sortKey="Weiss, Ep" uniqKey="Weiss E">EP Weiss</name></author><author><name sortKey="Racette, Sb" uniqKey="Racette S">SB Racette</name></author><author><name sortKey="Steger May, K" uniqKey="Steger May K">K Steger-May</name></author><author><name sortKey="Schechtman, Kb" uniqKey="Schechtman K">KB Schechtman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shapses, Sa" uniqKey="Shapses S">SA Shapses</name></author><author><name sortKey="Sukumar, D" uniqKey="Sukumar D">D Sukumar</name></author><author><name sortKey="Schneider, Sh" uniqKey="Schneider S">SH Schneider</name></author><author><name sortKey="Schlussel, Y" uniqKey="Schlussel Y">Y Schlussel</name></author><author><name sortKey="Sherrell, Rm" uniqKey="Sherrell R">RM Sherrell</name></author><author><name sortKey="Field, Mp" uniqKey="Field M">MP Field</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shapses, Sa" uniqKey="Shapses S">SA Shapses</name></author><author><name sortKey="Sukumar, D" uniqKey="Sukumar D">D Sukumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hinton, Ps" uniqKey="Hinton P">PS Hinton</name></author><author><name sortKey="Rector, Rs" uniqKey="Rector R">RS Rector</name></author><author><name sortKey="Donnelly, Je" uniqKey="Donnelly J">JE Donnelly</name></author><author><name sortKey="Smith, Bk" uniqKey="Smith B">BK Smith</name></author><author><name sortKey="Bailey, B" uniqKey="Bailey B">B Bailey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pop, Lc" uniqKey="Pop L">LC Pop</name></author><author><name sortKey="Sukumar, D" uniqKey="Sukumar D">D Sukumar</name></author><author><name sortKey="Tomaino, K" uniqKey="Tomaino K">K Tomaino</name></author><author><name sortKey="Schlussel, Y" uniqKey="Schlussel Y">Y Schlussel</name></author><author><name sortKey="Schneider, Sh" uniqKey="Schneider S">SH Schneider</name></author><author><name sortKey="Gordon, Cl" uniqKey="Gordon C">CL Gordon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Armamento Villareal, R" uniqKey="Armamento Villareal R">R Armamento-Villareal</name></author><author><name sortKey="Sadler, C" uniqKey="Sadler C">C Sadler</name></author><author><name sortKey="Napoli, N" uniqKey="Napoli N">N Napoli</name></author><author><name sortKey="Shah, K" uniqKey="Shah K">K Shah</name></author><author><name sortKey="Chode, S" uniqKey="Chode S">S Chode</name></author><author><name sortKey="Sinacore, Dr" uniqKey="Sinacore D">DR Sinacore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bielohuby, M" uniqKey="Bielohuby M">M Bielohuby</name></author><author><name sortKey="Matsuura, M" uniqKey="Matsuura M">M Matsuura</name></author><author><name sortKey="Herbach, N" uniqKey="Herbach N">N Herbach</name></author><author><name sortKey="Kienzle, E" uniqKey="Kienzle E">E Kienzle</name></author><author><name sortKey="Slawik, M" uniqKey="Slawik M">M Slawik</name></author><author><name sortKey="Hoeflich, A" uniqKey="Hoeflich A">A Hoeflich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ricci, Ta" uniqKey="Ricci T">TA Ricci</name></author><author><name sortKey="Heymsfield, Sb" uniqKey="Heymsfield S">SB Heymsfield</name></author><author><name sortKey="Pierson, Rn" uniqKey="Pierson R">RN Pierson</name></author><author><name sortKey="Stahl, T" uniqKey="Stahl T">T Stahl</name></author><author><name sortKey="Chowdhury, Ha" uniqKey="Chowdhury H">HA Chowdhury</name></author><author><name sortKey="Shapses, Sa" uniqKey="Shapses S">SA Shapses</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alberti, Kg" uniqKey="Alberti K">KG Alberti</name></author><author><name sortKey="Zimmet, P" uniqKey="Zimmet P">P Zimmet</name></author><author><name sortKey="Shaw, J" uniqKey="Shaw J">J Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Scherer, Pe" uniqKey="Scherer P">PE Scherer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Swanberg, M" uniqKey="Swanberg M">M Swanberg</name></author><author><name sortKey="Mcguigan, Fe" uniqKey="Mcguigan F">FE McGuigan</name></author><author><name sortKey="Ivaska, Kk" uniqKey="Ivaska K">KK Ivaska</name></author><author><name sortKey="Gerdhem, P" uniqKey="Gerdhem P">P Gerdhem</name></author><author><name sortKey="Akesson, K" uniqKey="Akesson K">K Akesson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guadalupe Grau, A" uniqKey="Guadalupe Grau A">A Guadalupe-Grau</name></author><author><name sortKey="Fuentes, T" uniqKey="Fuentes T">T Fuentes</name></author><author><name sortKey="Guerra, B" uniqKey="Guerra B">B Guerra</name></author><author><name sortKey="Calbet, Ja" uniqKey="Calbet J">JA Calbet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shah, K" uniqKey="Shah K">K Shah</name></author><author><name sortKey="Armamento Villareal, R" uniqKey="Armamento Villareal R">R Armamento-Villareal</name></author><author><name sortKey="Parimi, N" uniqKey="Parimi N">N Parimi</name></author><author><name sortKey="Chode, S" uniqKey="Chode S">S Chode</name></author><author><name sortKey="Sinacore, Dr" uniqKey="Sinacore D">DR Sinacore</name></author><author><name sortKey="Hilton, Tn" uniqKey="Hilton T">TN Hilton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pritchard, Je" uniqKey="Pritchard J">JE Pritchard</name></author><author><name sortKey="Nowson, Ca" uniqKey="Nowson C">CA Nowson</name></author><author><name sortKey="Wark, Jd" uniqKey="Wark J">JD Wark</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fappa, E" uniqKey="Fappa E">E Fappa</name></author><author><name sortKey="Yannakoulia, M" uniqKey="Yannakoulia M">M Yannakoulia</name></author><author><name sortKey="Pitsavos, C" uniqKey="Pitsavos C">C Pitsavos</name></author><author><name sortKey="Skoumas, I" uniqKey="Skoumas I">I Skoumas</name></author><author><name sortKey="Valourdou, S" uniqKey="Valourdou S">S Valourdou</name></author><author><name sortKey="Stefanadis, C" uniqKey="Stefanadis C">C Stefanadis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dutheil, F" uniqKey="Dutheil F">F Dutheil</name></author><author><name sortKey="Lac, G" uniqKey="Lac G">G Lac</name></author><author><name sortKey="Lesourd, B" uniqKey="Lesourd B">B Lesourd</name></author><author><name sortKey="Chapier, R" uniqKey="Chapier R">R Chapier</name></author><author><name sortKey="Walther, G" uniqKey="Walther G">G Walther</name></author><author><name sortKey="Vinet, A" uniqKey="Vinet A">A Vinet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dutheil, F" uniqKey="Dutheil F">F Dutheil</name></author><author><name sortKey="Walther, G" uniqKey="Walther G">G Walther</name></author><author><name sortKey="Chapier, R" uniqKey="Chapier R">R Chapier</name></author><author><name sortKey="Mnatzaganian, G" uniqKey="Mnatzaganian G">G Mnatzaganian</name></author><author><name sortKey="Lesourd, B" uniqKey="Lesourd B">B Lesourd</name></author><author><name sortKey="Naughton, G" uniqKey="Naughton G">G Naughton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamel, Eg" uniqKey="Kamel E">EG Kamel</name></author><author><name sortKey="Mcneill, G" uniqKey="Mcneill G">G McNeill</name></author><author><name sortKey="Han, Ts" uniqKey="Han T">TS Han</name></author><author><name sortKey="Smith, Fw" uniqKey="Smith F">FW Smith</name></author><author><name sortKey="Avenell, A" uniqKey="Avenell A">A Avenell</name></author><author><name sortKey="Davidson, L" uniqKey="Davidson L">L Davidson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silcocks, P" uniqKey="Silcocks P">P Silcocks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dutheil, F" uniqKey="Dutheil F">F Dutheil</name></author><author><name sortKey="Lac, G" uniqKey="Lac G">G Lac</name></author><author><name sortKey="Courteix, D" uniqKey="Courteix D">D Courteix</name></author><author><name sortKey="Dore, E" uniqKey="Dore E">E Dore</name></author><author><name sortKey="Chapier, R" uniqKey="Chapier R">R Chapier</name></author><author><name sortKey="Roszyk, L" uniqKey="Roszyk L">L Roszyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baxter Jones, Ad" uniqKey="Baxter Jones A">AD Baxter-Jones</name></author><author><name sortKey="Mirwald, Rl" uniqKey="Mirwald R">RL Mirwald</name></author><author><name sortKey="Mckay, Ha" uniqKey="Mckay H">HA McKay</name></author><author><name sortKey="Bailey, Da" uniqKey="Bailey D">DA Bailey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackowski, Sa" uniqKey="Jackowski S">SA Jackowski</name></author><author><name sortKey="Baxter Jones, Ad" uniqKey="Baxter Jones A">AD Baxter-Jones</name></author><author><name sortKey="Gruodyte Raciene, R" uniqKey="Gruodyte Raciene R">R Gruodyte-Raciene</name></author><author><name sortKey="Kontulainen, Sa" uniqKey="Kontulainen S">SA Kontulainen</name></author><author><name sortKey="Erlandson, Mc" uniqKey="Erlandson M">MC Erlandson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slinker, Bk" uniqKey="Slinker B">BK Slinker</name></author><author><name sortKey="Glantz, Sa" uniqKey="Glantz S">SA Glantz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bemben, Da" uniqKey="Bemben D">DA Bemben</name></author><author><name sortKey="Bemben, Mg" uniqKey="Bemben M">MG Bemben</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jensen, Lb" uniqKey="Jensen L">LB Jensen</name></author><author><name sortKey="Quaade, F" uniqKey="Quaade F">F Quaade</name></author><author><name sortKey="Sorensen, Oh" uniqKey="Sorensen O">OH Sorensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Compston, Je" uniqKey="Compston J">JE Compston</name></author><author><name sortKey="Laskey, Ma" uniqKey="Laskey M">MA Laskey</name></author><author><name sortKey="Croucher, Pi" uniqKey="Croucher P">PI Croucher</name></author><author><name sortKey="Coxon, A" uniqKey="Coxon A">A Coxon</name></author><author><name sortKey="Kreitzman, S" uniqKey="Kreitzman S">S Kreitzman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hyldstrup, L" uniqKey="Hyldstrup L">L Hyldstrup</name></author><author><name sortKey="Andersen, T" uniqKey="Andersen T">T Andersen</name></author><author><name sortKey="Mcnair, P" uniqKey="Mcnair P">P McNair</name></author><author><name sortKey="Breum, L" uniqKey="Breum L">L Breum</name></author><author><name sortKey="Transbol, I" uniqKey="Transbol I">I Transbol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kemmler, W" uniqKey="Kemmler W">W Kemmler</name></author><author><name sortKey="Von Stengel, S" uniqKey="Von Stengel S">S von Stengel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santhanakrishnan, I" uniqKey="Santhanakrishnan I">I Santhanakrishnan</name></author><author><name sortKey="Lakshminarayanan, S" uniqKey="Lakshminarayanan S">S Lakshminarayanan</name></author><author><name sortKey="Kar, Ss" uniqKey="Kar S">SS Kar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishikawa, S" uniqKey="Ishikawa S">S Ishikawa</name></author><author><name sortKey="Kim, Y" uniqKey="Kim Y">Y Kim</name></author><author><name sortKey="Kang, M" uniqKey="Kang M">M Kang</name></author><author><name sortKey="Morgan, Dw" uniqKey="Morgan D">DW Morgan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolff, I" uniqKey="Wolff I">I Wolff</name></author><author><name sortKey="Van Croonenborg, Jj" uniqKey="Van Croonenborg J">JJ van Croonenborg</name></author><author><name sortKey="Kemper, Hc" uniqKey="Kemper H">HC Kemper</name></author><author><name sortKey="Kostense, Pj" uniqKey="Kostense P">PJ Kostense</name></author><author><name sortKey="Twisk, Jw" uniqKey="Twisk J">JW Twisk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Chihaoui, M" uniqKey="Ben Chihaoui M">M Ben Chihaoui</name></author><author><name sortKey="Elleuch, M" uniqKey="Elleuch M">M Elleuch</name></author><author><name sortKey="Sahli, H" uniqKey="Sahli H">H Sahli</name></author><author><name sortKey="Cheour, I" uniqKey="Cheour I">I Cheour</name></author><author><name sortKey="Romdhane, Rh" uniqKey="Romdhane R">RH Romdhane</name></author><author><name sortKey="Sellami, S" uniqKey="Sellami S">S Sellami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, Tj" uniqKey="Martin T">TJ Martin</name></author><author><name sortKey="Seeman, E" uniqKey="Seeman E">E Seeman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dutheil, F" uniqKey="Dutheil F">F Dutheil</name></author><author><name sortKey="Lesourd, B" uniqKey="Lesourd B">B Lesourd</name></author><author><name sortKey="Courteix, D" uniqKey="Courteix D">D Courteix</name></author><author><name sortKey="Chapier, R" uniqKey="Chapier R">R Chapier</name></author><author><name sortKey="Dore, E" uniqKey="Dore E">E Dore</name></author><author><name sortKey="Lac, G" uniqKey="Lac G">G Lac</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beverly, Mc" uniqKey="Beverly M">MC Beverly</name></author><author><name sortKey="Rider, Ta" uniqKey="Rider T">TA Rider</name></author><author><name sortKey="Evans, Mj" uniqKey="Evans M">MJ Evans</name></author><author><name sortKey="Smith, R" uniqKey="Smith R">R Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Labouesse, Ma" uniqKey="Labouesse M">MA Labouesse</name></author><author><name sortKey="Gertz, Er" uniqKey="Gertz E">ER Gertz</name></author><author><name sortKey="Piccolo, Bd" uniqKey="Piccolo B">BD Piccolo</name></author><author><name sortKey="Souza, Ec" uniqKey="Souza E">EC Souza</name></author><author><name sortKey="Schuster, Gu" uniqKey="Schuster G">GU Schuster</name></author><author><name sortKey="Witbracht, Mg" uniqKey="Witbracht M">MG Witbracht</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarkis, Ks" uniqKey="Sarkis K">KS Sarkis</name></author><author><name sortKey="Pinheiro Mde, M" uniqKey="Pinheiro Mde M">M Pinheiro Mde</name></author><author><name sortKey="Szejnfeld, Vl" uniqKey="Szejnfeld V">VL Szejnfeld</name></author><author><name sortKey="Martini, La" uniqKey="Martini L">LA Martini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Theodoratou, E" uniqKey="Theodoratou E">E Theodoratou</name></author><author><name sortKey="Tzoulaki, I" uniqKey="Tzoulaki I">I Tzoulaki</name></author><author><name sortKey="Zgaga, L" uniqKey="Zgaga L">L Zgaga</name></author><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chaplais, E" uniqKey="Chaplais E">E Chaplais</name></author><author><name sortKey="Thivel, D" uniqKey="Thivel D">D Thivel</name></author><author><name sortKey="Greene, D" uniqKey="Greene D">D Greene</name></author><author><name sortKey="Dutheil, F" uniqKey="Dutheil F">F Dutheil</name></author><author><name sortKey="Duche, P" uniqKey="Duche P">P Duche</name></author><author><name sortKey="Naughton, G" uniqKey="Naughton G">G Naughton</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Portugal</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Avignon</li><li>Clermont-Ferrand</li></settlement></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name></region><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Ferry, Beatrice" sort="Ferry, Beatrice" uniqKey="Ferry B" first="Béatrice" last="Ferry">Béatrice Ferry</name><name sortKey="Ferry, Beatrice" sort="Ferry, Beatrice" uniqKey="Ferry B" first="Béatrice" last="Ferry">Béatrice Ferry</name><name sortKey="Lac, Gerard" sort="Lac, Gerard" uniqKey="Lac G" first="Gérard" last="Lac">Gérard Lac</name><name sortKey="Lac, Gerard" sort="Lac, Gerard" uniqKey="Lac G" first="Gérard" last="Lac">Gérard Lac</name><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name><name sortKey="Marceau, Geoffroy" sort="Marceau, Geoffroy" uniqKey="Marceau G" first="Geoffroy" last="Marceau">Geoffroy Marceau</name><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name><name sortKey="Vinet, Agnes" sort="Vinet, Agnes" uniqKey="Vinet A" first="Agnès" last="Vinet">Agnès Vinet</name><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name></country><country name="Australie"><noRegion><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name></noRegion><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frédéric" last="Dutheil">Frédéric Dutheil</name><name sortKey="Naughton, Geraldine" sort="Naughton, Geraldine" uniqKey="Naughton G" first="Geraldine" last="Naughton">Geraldine Naughton</name></country><country name="Portugal"><noRegion><name sortKey="Valente Dos Santos, Joao" sort="Valente Dos Santos, Joao" uniqKey="Valente Dos Santos J" first="João" last="Valente-Dos-Santos">João Valente-Dos-Santos</name></noRegion><name sortKey="Joao Coelho E Silva, Manuel" sort="Joao Coelho E Silva, Manuel" uniqKey="Joao Coelho E Silva M" first="Manuel" last="João Coelho-E-Silva">Manuel João Coelho-E-Silva</name><name sortKey="Valente Dos Santos, Joao" sort="Valente Dos Santos, Joao" uniqKey="Valente Dos Santos J" first="João" last="Valente-Dos-Santos">João Valente-Dos-Santos</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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